Key Publications
Hossain MS, Sansam CG, Wittig KA, Noble TD, Boyd KA, Sansam CL. Dynamic regulation of origin firing factors links CDK activity to dormant origin activation. Nat Commun (2026). doi.org/10.1038/s41467-026-73333-4
Noble, T. D., Sansam, C. G., Wittig, K. A., Majchrzycka, B., Sansam, C. L. Cell Cycle-Dependent TICRR/TRESLIN and MTBP Chromatin Binding Mechanisms and Patterns. Genome Biol. 2025 Jul 7;26(1):194, doi.org/10.1186/s13059-025-03665-9 (2025).
Masser E.A., Noble T.D., Siefert J.C., Goins D., Sansam C.G., Sansam C.L. Zebrafish Rif1 impacts zygotic genome activation, replication timing, and sex determination. eLife 12:RP87671, doi.org/10.7554/eLife.87671.1 (2023).
Wittig, K. A., Sansam, C. G., Noble, T. D., Goins, D. & Sansam, C. L. The CRL4DTL E3 ligase induces degradation of the DNA replication initiation factor TICRR/TRESLIN specifically during S phase. Nucleic Acids Res 49, 10507-10523, doi:10.1093/nar/gkab805 (2021).
Sansam, C. G. et al. A mechanism for epigenetic control of DNA replication. Genes Dev 32, 224-229, doi:10.1101/gad.306464.117 (2018).
Recognized by Faculty of 1000.
Siefert, J. C., Georgescu, C., Wren, J. D., Koren, A. & Sansam, C. L. DNA replication timing during development anticipates transcriptional programs and parallels enhancer activation. Genome Res 27, 1406-1416, doi:10.1101/gr.218602.116 (2017).
Recognized by Faculty of 1000.
Selected Publications
Sansam CG, Masser EA, Goins D, Sansam CL. Due-B Is dispensable for early development and genome duplication in vertebrates. bioRxiv [Preprint]. 2025 Jun 17:2025.06.17.658125. doi: 10.1101/2025.06.17.658125.(2025)
DuBose CO, Daum JR, Sansam CL, Gorbsky GJ. Dynamic Features of Chromosomal Instability during Culture of Induced Pluripotent Stem Cells. Genes (Basel). 2022 Jun 27;13(7):1157. doi: 10.3390/genes13071157.(2022)
Hulke, M. L., Siefert, J. C., Sansam, C. L. & Koren, A. Germline Structural Variations Are Preferential Sites of DNA Replication Timing Plasticity during Development. Genome Biol Evol 11, 1663-1678, doi:10.1093/gbe/evz098 (2019).
Siefert, J. C., Clowdus, E. A., Goins, D., Koren, A. & Sansam, C. L. Profiling DNA Replication Timing Using Zebrafish as an In Vivo Model System. J Vis Exp, doi:10.3791/57146 (2018).
Siefert, J. C., Georgescu, C., Wren, J. D., Koren, A. & Sansam, C. L. DNA replication timing during development anticipates transcriptional programs and parallels enhancer activation. Genome Res 27, 1406-1416, doi:10.1101/gr.218602.116 (2017).
Recognized by Faculty of 1000.
Alomer, R. M. et al. Esco1 and Esco2 regulate distinct cohesin functions during cell cycle progression. Proc Natl Acad Sci U S A 114, 9906-9911, doi:10.1073/pnas.1708291114 (2017).
Siefert, J. C., Clowdus, E. A. & Sansam, C. L. Cell cycle control in the early embryonic development of aquatic animal species. Comp Biochem Physiol C Toxicol Pharmacol 178, 8-15, doi:10.1016/j.cbpc.2015.10.003 (2015).
Sansam, C. G., Goins, D., Siefert, J. C., Clowdus, E. A. & Sansam, C. L. Cyclin-dependent kinase regulates the length of S phase through TICRR/TRESLIN phosphorylation. Genes Dev 29, 555-566, doi:10.1101/gad.246827.114 (2015).
Sansam, C. L. et al. A vertebrate gene, ticrr, is an essential checkpoint and replication regulator. Genes Dev 24, 183-194, doi:10.1101/gad.1860310 (2010).
Sansam, C. L. et al. DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint. Genes Dev 20, 3117-3129, doi:10.1101/gad.1482106 (2006).