Key Publications
Noble, T. D., Sansam, C. G., Wittig, K. A., Majchrzycka, B., Sansam, C. L. Cell Cycle-Dependent TICRR/TRESLIN and MTBP Chromatin Binding Mechanisms and Patterns. bioRxiv [Preprint], doi.org/10.1101/2024.02.02.578516 (2024).
Masser E.A., Noble T.D., Siefert J.C., Goins D., Sansam C.G., Sansam C.L. Zebrafish Rif1 impacts zygotic genome activation, replication timing, and sex determination. eLife 12:RP87671, doi.org/10.7554/eLife.87671.1 (2023).
Wittig, K. A., Sansam, C. G., Noble, T. D., Goins, D. & Sansam, C. L. The CRL4DTL E3 ligase induces degradation of the DNA replication initiation factor TICRR/TRESLIN specifically during S phase. Nucleic Acids Res 49, 10507-10523, doi:10.1093/nar/gkab805 (2021).
Sansam, C. G. et al. A mechanism for epigenetic control of DNA replication. Genes Dev 32, 224-229, doi:10.1101/gad.306464.117 (2018).
Recognized by Faculty of 1000.
Siefert, J. C., Georgescu, C., Wren, J. D., Koren, A. & Sansam, C. L. DNA replication timing during development anticipates transcriptional programs and parallels enhancer activation. Genome Res 27, 1406-1416, doi:10.1101/gr.218602.116 (2017).
Recognized by Faculty of 1000.
Selected Publications
Wittig, K. A., Sansam, C. G., Noble, T. D., Goins, D. & Sansam, C. L. The CRL4DTL E3 ligase induces degradation of the DNA replication initiation factor TICRR/TRESLIN specifically during S phase. Nucleic Acids Res 49, 10507-10523, doi:10.1093/nar/gkab805 (2021).
Hulke, M. L., Siefert, J. C., Sansam, C. L. & Koren, A. Germline Structural Variations Are Preferential Sites of DNA Replication Timing Plasticity during Development. Genome Biol Evol 11, 1663-1678, doi:10.1093/gbe/evz098 (2019).
Siefert, J. C., Clowdus, E. A., Goins, D., Koren, A. & Sansam, C. L. Profiling DNA Replication Timing Using Zebrafish as an In Vivo Model System. J Vis Exp, doi:10.3791/57146 (2018).
Sansam, C. G. et al. A mechanism for epigenetic control of DNA replication. Genes Dev 32, 224-229, doi:10.1101/gad.306464.117 (2018).
Recognized by Faculty of 1000.
Siefert, J. C., Georgescu, C., Wren, J. D., Koren, A. & Sansam, C. L. DNA replication timing during development anticipates transcriptional programs and parallels enhancer activation. Genome Res 27, 1406-1416, doi:10.1101/gr.218602.116 (2017).
Recognized by Faculty of 1000.
Alomer, R. M. et al. Esco1 and Esco2 regulate distinct cohesin functions during cell cycle progression. Proc Natl Acad Sci U S A 114, 9906-9911, doi:10.1073/pnas.1708291114 (2017).
Siefert, J. C., Clowdus, E. A. & Sansam, C. L. Cell cycle control in the early embryonic development of aquatic animal species. Comp Biochem Physiol C Toxicol Pharmacol 178, 8-15, doi:10.1016/j.cbpc.2015.10.003 (2015).
Sansam, C. G., Goins, D., Siefert, J. C., Clowdus, E. A. & Sansam, C. L. Cyclin-dependent kinase regulates the length of S phase through TICRR/TRESLIN phosphorylation. Genes Dev 29, 555-566, doi:10.1101/gad.246827.114 (2015).
Sansam, C. L. et al. A vertebrate gene, ticrr, is an essential checkpoint and replication regulator. Genes Dev 24, 183-194, doi:10.1101/gad.1860310 (2010).
Sansam, C. L. et al. DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint. Genes Dev 20, 3117-3129, doi:10.1101/gad.1482106 (2006).